POLLUTAMIN-PM2.5: SILVER LINING IN THE CLOUD OF POLLUTION
Air Pollution is causing Airborne Diseases Coughing, sneezing, upper respiratory infection, running nose, etc. These can be the symptoms of allergy due to pollution. With the advancement science has made, our globe is becoming more prone to pollution. Cutting down of such a large number of trees, smoke emitted by industries (which are increasing every day), more reliability on machines like vehicles, etc, are few of the many reasons. We humans have become the culprit and the victim of pollution at the same time. THIS IS ALARMING! People coming out for morning walks with their masks on have become a common sight, especially in metro cities. Pollution has reached (or rather crossed) a level beyond which, it would start affecting the health of the humans. More and more people are becoming patients of Asthma, Bronchitis, lung infection, and many other pollution-based diseases. Symptoms Of Allergy Sudden coughing or sneezing when exposed to air. Might be dry coughing. Running nose Stuffy nose Headache Difficulty in breathing We believe in becoming a part of the solution and not pollution. Hence, Pollutamin-PM2.5 has been introduced after much of the research, and experiments were done. Curcumin (the ingredient of turmeric, Curcuma longa) based this anti-allergic helps in relieving pollution borne diseases. The therapeutic effects of turmeric towards the lungs and other respiratory disorders are not new. Curcumin, the ingredient of Turmeric, is the cause of the therapeutic effect. Pollutamin-PM2.5 contains the right levels of curcumin needed to kick the air pollution based disorders. Why Pollutamin-PM2.5? You CAN’T control pollution in a day, and you know it. Small allergies can lead to major chronic disorders. Allergy can be developed anytime in life. You might not be born with it. Pollutamin-PM2.5 would not only cure but would also curb any allergic diseases. (Prevention is better than cure, even a child knows!) Diseases like Asthma start with allergies! Polluted air is full of viruses and bacteria’s which cause allergic infection. These bacteria’s may be of different types. The antibacterial and antiviral properties of curcumin help your body fight these allergens, naturally. Curcumin holds anti-inflammatory and antioxidant properties, both beneficial in airborne diseases. Anything that helps in treating chronic inflammation not only prevents but cures the diseases. What Is Pollutamin-PM2.5? Pollutamin-PM2.5 is exclusively developed to cure the diseases caused due to air pollution. Turmeric is good for such airborne infections, you know. But organically developed and processed product containing the exact amount of curcumin needed is even better. Pollutamin-PM2.5 it is! It is free from any types of any chemicals or chemical-based fertilizers. At Bagdara Farms it’s made sure that each turmeric module is far off from any chemical fertilizer touching it. Why Is Pollutamin-PM2.5 Safe? In a world full of adulteration, we know it’s a little difficult to trust anything. Then why trust Pollutamin-PM2.5? Well, we don’t ask you to trust us but to believe the formula of our forefathers. They knew the hidden magical power of turmeric. It had never been just a spice to add color but a boon to add to your good health. Organically developed, processed, and packaged this product is something we can swear by. It is research and scientific experiments done by experts who have proved the therapeutic effects of this product. We understand how difficult it is to combat pollution and related problems with the type of lifestyle we deal today. We aren’t sure of the air we breathe in and the environment we live in. Smoke and other industrial wastes took away the freshness of the air long back. It will be a little bit difficult to kill pollution. Even if we do, there’s a long time to go! Till then we can rely on such natural turmeric-based products which our ancestors have always banked upon. Until we fight pollution completely, let Pollutamin-PM2.5 be your bae!
CAN CURCUMIN BREATHE NEW LIFE INTO YOUR POLLUTION STRICKEN BODY?
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/02/pollutamin-PM-2.5-article.mp3″] Since as early as 1952 when the great London Fog killed 4000 people, nature has tried to warn the man about how harmful air pollution can be. In big cities especially in developing countries, it is commonplace to see thick sheets of dense smog during certain times of the year. While there are external factors that cause a significant part of PM2.5 suspension like winds that blow desert sands all the way from the Middle East towards countries like India during the winter months, it cannot be denied that the smoke emitted by vehicles, the burning of crop, the open bonfires that can be spotted here and there and industrial emissions add manifold to the problem. As Per The World Health Organization, There Are Six Main Air Pollutants. These Are: Particle pollution Carbon monoxide Lead Sulphur oxides Ground level ozone Nitrogen oxides When human beings are exposed to these pollutants for a prolonged period, they are likely to suffer from serious medical issues that can range from respiratory problems to cardiovascular issues to neurological malfunctions to skin and eye infections. Particulate Matter And Its Deadly Effects On Health Out of all the air mentioned above pollutants, one of the most damaging element is the pollution caused by particulate matter. Particulate matter (PM) is very bad for health since it adversely affects the cardio-pulmonary system. Another statistic published by the World Health Organization suggests that PM-related air pollution causes roughly 800,000 deaths per year [1]. Particulate matter is a lethal mixture of minute particles and liquid droplets that consist of dust particles, acids, and other irritants. Particulate Matter can be classified based on the size of the particles. For instance, if the size of the particles is less than 2.5 micrometers, then they are known as PM2.5. This is the most dangerous kind of PM as it tends to embed themselves into the air passages and cause respiratory problems. They are also linked to coronary artery disease since they negatively affect the coagulation process and platelet activation [2]. Curcumin – A Natural Remedy For Health Effects Of PM Related Air Pollution Curcumin is a polyphenol found in turmeric. It is the main reason behind many of the therapeutic qualities found in turmeric. There are several characteristics of curcumin that help tone down the severity of the health effects perpetrated by prolonged exposure to particulate matter. Here are some ways in which it can help people fight the adverse effects of air pollution on health: A study conducted by Zhiguo Zhang and team [3] and team has gone to prove that curcumin has a positive effect on human bronchial epithelial cells or HBEC that have been exposed to PM2.5 for a long duration. It also states that curcumin has antioxidant and anti-inflammatory properties that are useful in protecting the human air passages from the harmful side effects of inhaling PM2.5 laced air. Another study carried out by Abderrrahim Nemmar and team has proven that curcumin can protect the respiratory and cardiovascular system from the hazardous effects of particulate matter produced by diesel engines by inhibiting the activity of tumor necrosis factor α (TNF α). This is because of the anti-inflammatory nature of curcumin [4]. Turmeric has fantastic expectorant properties. When mixed with other natural phlegm loosening agents like onions or ginger and honey, it can be very effective in decongesting the airways that have been congested due to extended exposure to PM2.5. Curcumin helps in detoxifying the body by boosting the function of the liver and the kidneys. Both the liver and the kidneys are organs that work towards eliminating the toxins from the body. Curcumin has broad spectrum anti-microbial properties that make it very useful when it comes to fighting lung infections arising from inhaling PM2.5 laden air. Many bacteria and viruses can be stopped in their tracks by taking a regular dose of curcumin every day. Bagdara Farms, an Indian agricultural venture, has taken a step towards helping people battle the menace that arises from PM2.5 induced air pollution using curcumin. A stretch of verdant farmland stretching across the Bandhavgarh forests, Bagdara farms has been devoted to the cultivation of high-quality curcumin that is grown using state-of-the-art organic farming techniques. As a result, the curcumin that comes out of Bagdara is top-notch and contains no chemical residues at all. Using this curcumin a supplement known as Pollutamin-PM2.5 is created that can help those fighting with air pollution across the world. Regular consumption of Pollutamin-PM2.5 has a protective effect on the cardiovascular as the respiratory system. Order your jar of Pollutamin-PM2.5 today and take the right steps towards saving your body from the PM2.5 monster!
Curcumin – A Superfood That Can Protect You From The Effects Of Air Pollution
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2022/03/apoorva-pollutamin.mp3″] Developing nations across the globe have recently come face to face with a sinister monster that has been birthed by the industrialization drives that have been underway for decades now. This rather scary fallout of industrial progress is air pollution. In India, air pollution has slowly crept up to the 5th position in a list of factors that can cause premature deaths. While factory chimneys and vehicle exhausts are the topmost contributors to this growing level of pollutants in the air, there are quite a few other factors that most people are unaware of. These include dust mites trapped in carpets and upholstery, smoke emanating from crop burning exercises, chemicals present in air fresheners, chemicals released by furniture varnish, and so on. Many people mistakenly believe that if they were to stay indoors they would be absolutely safe from polluted air. While staying indoors cuts down your exposure to harmful gases emitted as part of vehicular smoke, there are still plenty of substances in the air at home that can cause quite a bit of damage to your body. Over time many studies have been conducted to zero in on remedies that are natural and can help improve your immunity so that you are better prepared to battle an onslaught of pollutants. Out of all the items that have been studied, there is one that has emerged as the most effective against the ill effects of air pollution – curcumin. A natural polyphenolic pigment found in turmeric, curcumin has been used as part of Ayurvedic recipes for years. It is believed to possess a rich cache of therapeutic qualities that can help manage many every day as well as complex illnesses better. In the case of air pollution, curcumin acts as a detoxifying agent that can help purge the toxins that have built up internally due to years of inhaling polluted air. Read How Curcumin Benefits in Battling the Outcomes of Air Pollution: Curcumin is a well-known anti-inflammatory agent that can act quickly on internal as well as external inflammation to reduce its intensity. One of the most nagging side effects of air pollution is respiratory inflammation that manifests in the form of agitated airways that cause shortness of breath, wheezing, and COPD or asthma-like symptoms. The anti-inflammatory mechanism of curcumin helps in tuning down the activity of pro-inflammatory enzymes in the body and hence reduces the swelling in the airways, therefore, making it easier for you to breathe. Curcumin has broad-spectrum anti-microbial properties that can help fight pollution-induced infections in the respiratory as well as cardiovascular systems. Even skin infections that are caused as a result of too much exposure to polluted air can be treated with the help of curcumin. Curcumin is very effective against pathogens of all kinds as it is able to target the pathogenic cells and induce apoptosis or cell death in them. Curcumin is a strong antioxidant that helps in reducing the level of oxidative stress in the body. Oxidative stress, a phenomenon that is triggered by overexposure to polluted air, occurs when the quantity of free radicals increases drastically in the body causing unfavourable results like premature ageing, chronic inflammation, and reduction of immune strength. Curcumin helps in balancing the pro-oxidant and antioxidant species in the body thereby effectively lowering the level of oxidative stress. Curcumin acts as a natural expectorant and can be consumed regularly to get rid of phlegmatic coughing and wheezing. A homemade cough remedy that consists of jaggery, curcumin powder, and clarified butter or ghee is very effective in reducing the swelling in the airways as well as loosening the phlegm that causes the persistent coughing and the wheezing. Pollutamin-PM2.5 is a very effective natural product that can help you fight the ill effects of the most terrible form of air pollutants known as Particulate Matter 2.5 or PM2.5. Pollutamin-PM2.5 is made by the kind folks at Bagdara Farms using curcumin that is organic and completely natural. Consumption of this supplement every day can help you get rid of all those awful side effects that are caused as a result of constant exposure to polluted air.
What Care Are You Taking For The Rising Pollution Levels?
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/rising-pollution-levels.mp3″] Smoke, smog, adulterated air etc. have become terms commonly used today. Reason? Pollution! And I need not mention how and why has the pollution increased tremendously since the past few years. And there seems to be no stopping to it. Side-Effects of Pollution The air pollution has increased as much as to be fatal. The death rates due to ambient air pollution in India are increasing with each passing day. The death rates in India due to air pollution crossed that of China’s back in 2015 itself! Government is doing many possible things to check the pollution. Some succeed while others don’t. But is that all? Will that sufficient it all? Pollution is affecting many lives, many breeds and many species. And we humans are no different. Pollution is causing many diseases majorly Asthma, Lung Cancer, Emphysema, Chronic Obstructive Pulmonary Diseases or else worsen the previously existing respiratory condition. The steps need to be taken. Not just to control pollution but also to prevent ourselves from getting diseased. Though we’re already doing much as preventing measures. From wearing masks to the usage of air purifiers, we see many of them practising this. Buy do they work? “Most people who buy air purifiers do so in hopes of easing asthma or allergies. … The very best portable models we tested were effective at cleaning the air of dust, smoke, and pollen at their highest and lowest speed. The worst models weren’t effective at any speed. Mar 20, 2017” as sourced from consumerreports.org. Steps That Can Be Taken To Combat The Side Effects of Pollution Air purifiers don’t work in the long run. They make you dependent on them by decreasing your immunity to fight the airborne diseases naturally. Imagine a life where you cannot survive without a purifier! Scary, isn’t it? Until we don’t reach out the goal of a pollutionless environment, do we not need to take some robust, effective measures to protect ourselves and our families? Something like wearing masks might be a temporary solution. We need to build our immunity strong enough to fight on its own. Something that doesn’t let any sorts of allergens or pollutants affect our bodies. Pollutamin-PM2.5 by Bagdara Farms is a natural way to fight the increased pollution. Pollutamin is specially formulated to combat the diseases due to the air pollution. It contains organic and natural curcumin which naturally possesses properties like antiseptic, anti-inflammatory, antiviral, antibacterial, immunomodulatory, analgesic etc. These properties work together in building up your immunity and keep the airborne diseases at bay. Polluted air contains bacteria, viruses and dust which are harmful to our health. Pollutamin-PM2.5 keeps you against all of them. It’s antimutagenic and immunomodulatory properties reduce the risk of lung cancer and Asthma. So until we find a way to combat pollution, we need to take measures which help fight the airborne diseases. Pollutamin-PM2.5 is one natural and organic way. What will your pick be then?
Living In A Polluted Area? Pollutamin-PM2.5 Is A Must For You.
We do not own the earth instead we share it with others, so whatever damage we cause to the earth we have to face the consequences. The harshest manner in which we damage the environment is by polluting the air we breathe and the water we drink and once the damage has been done the effects come back to bite us in the form of various ailments which can vary from minor health issues to life-threatening diseases. We release pollutants into the air daily when we drive our cars, turn on the AC’s on our plush offices, emit poisonous smoke into the air, and all of these make our clean, pure air unbreathable. When we Breathe in the Polluted Air: We are susceptible to breathing problems like asthma Exposure to polluted air for 6-7 hours hampers our lung function and can lead to inflamed lings. Most of the pollutants in the air have a carcinogenic effect and exposure to such air puts one in the high-risk zone of developing cancer. City folks are continuously battling coughing and wheezing. Pollution has a lasting negative impact on some of our systems especially the immune system, endocrine system and the reproductive system. We are facing the harshest effect regarding the changing weather brought on by global warming. Air pollution plays havoc with our heart, and more damage takes place if we do not get clean air to breathe. Even the plants and animals are not spared, and when we consume these we are affected too(9 food chain syndrome) Exposure to polluted air leads to the risk of miscarriages, premature birth, autism spectrum disorder and asthma in children. These effects are visible all around us with children as young as five falling victims to asthma. We haven’t spared the water either we contaminate it by throwing waste, letting out effluents when we drink contaminated water We are prone to water-borne problems like amoebiasis, typhoid, and hookworms Drinking water that has been polluted by chemicals, heavy metals, pesticides increases the risk of damage to the reproductive system and can cause hormonal imbalance issues, damage to the kidney and liver and cancer. If the water has high mercury then being exposed to that can lead to Alzheimer’s and even Parkinson’s and can be fatal in some cases. If you come in contact with polluted water( beach), you might break into a rash or develop hepatitis, gastroenteritis, diarrhea, encephalitis, Marine life is not spared either and consuming seafood means you are not spared the consequences. All of these effects have the power to cut a healthy life short and make us sick in ways that would make life very difficult. The perfect solution is first and foremost to reduce and stop polluting the environment, and yes we need to look at a natural way of fighting off the effects of pollution. How Curcumin helps in combating pollution side-effects We need to look at natural ways of fortifying our immune system and internal health so that we can ward off the ill-effects of pollution. The one natural ingredient that stands tall is Curcumin. Curcumin has proven efficacy when it comes to boosting the immune system and allaying the ill-effects of pollution. Our cardiovascular system takes a beating at the hand of particulate pollutants, but Curcumin has the efficacy to slay these effects owing to its compelling anti-oxidant action. It inhibits the oxidant cytokine, and this helps in protecting the epithelial lining Curcumin has proven efficacy against the impact of cadmium exposure( industrial and environmental pollution) The potent anti-inflammatory action of curcumin works wonders in providing relief. Curcumin is a dynamic anti-carcinogenic, and it helps ward off the effects of cancer and checks the growth of abnormal cells The anti-carcinogenic impact of curcumin checks cancers spread and in some cases reverses cancer. The singularly potent anti-viral and antibacterial property of curcumin have a mercurial effect on warding off the effects of pollution. Curcumin has an anti-inflammatory action second to none and as inflammation is the underlying cause of all ailments once that has been checked the disease might get nipped in the nascent stage itself. How to ensure that you get the Best Curcumin Look for supplements that boast of pure organic curcumin with black pepper and fat. Bagdara farms have Curcumin products with Curcumin which is 100% organic, and the purity is guaranteed as no pesticides or insecticides are used. It comes with the right amount of black pepper which ensures Curcumin gets absorbed and you get the multitude benefits that it gives. Do your bit to prevent pollution but also bolster your internal strength with Curcumin. Pollutamin-PM2.5 from Bagdara Farms is the best remedy for combating the side-effects of pollution.
Treat the Effects of Pollution Naturally By Curcumin Product: Pollutamin
Pollution is defined as the introduction of a harmful or poisonous substance into the environment. Of all the various types of pollution, air pollution is turning out to be the most detrimental to health in the recent times. Not only the metropolitan cities but the small towns are also grappling with the issue of air pollution. Air being a medium as well as carrier can transfer the pollutants faster. Thus making it obvious for a person breathing to get an infection. But we can treat the harmful effects of pollution naturally with Curcumin. Anuja is a 10 year old and has to travel long hours in the bus to and fro school. Her asthma gets worse due to the high pollution levels of the city. In Asthma, the chronic inflammation of the air passages happens making it difficult to breathe. The particulate matter, oxides of sulphur and nitrogen, tobacco smoke can aggravate the symptoms of asthma. Varun is a 34 year old man and is suffering from the symptoms of COPD (Chronic Obstructive Pulmonary Disease). This condition is caused when air passages and air sacs change their shape and become distended, because of which the patient finds it hard to breathe even while sitting. The two types of COPD are Emphysema and Chronic bronchitis which can lead to cancer and even death. The people who are working in docks, mines and quarries. These people work in an environment full of dust and fumes are at more risk. Samar had resumed work after a bout of pneumonia but to everyone’s surprise, he again started showing symptoms of the disease. On investigation, it was revealed that the bacteria present in the polluted air enters the respiratory tract and makes the person more prone to contracting pneumonia. How does Air Pollution Harm Your Body? Air pollution can also cause weakening of the lung function which can be seen in many forms. Some of them are allergies, panting, low immunity to cold and cough. Lung cancer is another disease that can be caused due to the presence of carcinogens in the polluted air. There are many defects in the new born and fetuses that can occur by ingestion of polluted air. They exhibit low immunity power against allergies and seasonal cough and cold. Inhaling of benzene vapors can also cause leukemia. According to a survey, air pollution from smoke and various chemicals is known to kill around 3 million people every year. Combustion of fossil fuels which are high in sulphur can create cid particles called sulphur oxides that get deposited in the upper respiratory tract and constrict the airways causing chronic bronchitis. The nanoparticle technology has many used but since the nanoparticles are very fine, they can cause the development of fluid around the lungs and damage them. The main problem with air pollutants is that they can travel long distances from their original source even in very small concentrations. Over a period of time, these low concentrations of contaminants can have its side effects. Moreover, the smog (smoke fog) in bigger cities is becoming a growing problem. Treat the Effects of Pollution Naturally By Curcumin One can imagine the number of medicines that one needs to take and treatment that one needs to undergo to combat the effects of air pollution. Mother Nature has given us a precious gift in curcumin and turmerone to fight air pollution. The best organically grown curcumin and turmerone can be found in a product called Pollutamin – PM 2.5 from Bagdara Farms. The best part about this product that it is free from any kind of chemical fertilizers. Since curcumin is an anti-inflammatory agent, it helps to prevent the oxidative stress, This is produced in the body while being exposed to a variety of air pollutants. The anticancer property of curcumin and turmerone also plays a major role in preventing various cancers like lung cancer and leukaemia. Curcumin can also prevent the production of certain cytokines and prevents the movement of immune cells to the site of inflammation. It also aids the detoxification function of liver which helps in removing all the major pollutants from the body. As far as the recommended dosages are concerned, it is always advisable that one starts taking this product in small quantities and then gradually increases the quantity. For 10 years and above Take ½ tsp Pollutamin PM2.5, ½ tsp ginger, cup of water. Bring all the ingredients and add honey. Drink this mixture twice a day. Take ½ tsp Pollutamin PM 2.5 with a pinch of salt in 1 cup of hot water every day in the morning. Take ½ tsp Pollutamin PM 2.5, 1 glass of water and ½ lemon juice. Mix all the ingredients and have it twice a day. Take ½ tsp Pollutamin PM 2.5, pinch of black pepper and 1 cup if milk and honey to taste. Boil milk, pepper and Pollutamin PM 2.5 together. Once boiled, add honey to taste. Drink this twice daily. It is to be noted that this product be avoided for children less than 2 years of age. So, now no more let your body get adversely affected with pollution. Treat the harmful affects of pollution with curcumin rich Pollutamin PM 2.5. Buy Pollutamin PM 2.5 here!
Nullify the Effects of Pollution with Pollutamin- PM2.5
The air that we inhale nowadays is totally polluted and has a lot of pollutants like exhaust particles, nitrogen oxide, particulate matter etc. All this goes in to our lungs and leads to harmful effects by attacking our immune system and cells. Free radicals are produced and they lead to inflammation being caused. In places like Delhi and other metropolitan cities, there are a lot of factors like fog and smoke that add to the pollution and make it worse. It even makes breathing difficult and is leading to many respiratory troubles and health hazards. But there is hope at with a new product developed by Bagdara Farms called Pollutamin- PM2.5. First off, we must know what is PM 2.5. Well, let’s find out. PM is the Particulate matter which is the particle pollution in the air. It is the mixture of liquid droplets and the solid particles that are in the air. There are some particles like dust, smoke, soot which are large and can be seen with the naked eye. Then there are some other particles that can only be detected with the help of a microscope as they are so tiny. These are PM 2.5 which are fine particles that can be inhaled with the air. Where does PM come from? The particulate matter particles are in various shapes and sizes and can come from various kinds of chemicals that are mixed in the air. Some may come directly from a source like fires, construction sites, fields that are being harvested etc. Whereas there are other particles that are the result of complex reactions that take place in the atmosphere. These are sulphur oxide, nitrogen oxides, carbon monoxide etc. They may come from vehicles, power plants and factories. What effect does PM have? Since PM is so small, it can be inhaled along with the air and lead to worrisome health issues. The particles that are less than 10 micrometers in diameters are most dangerous since they get deep set into the lungs or may enter the bloodstream causing some serious health hazards. 5 is the main cause of the lower visibility in cities like Delhi that is the current problem. The particles of PM 2.5 can go very deep into the respiratory tract and can reach the lungs too. Short-term effects of these particles on the health are running nose, irritation in the throat and eyes, coughing and short breath. But prolonged PM2.5 exposure can lead to heart diseases and asthma. There may also be increased rate of deaths due to lung cancer and heart conditions, chronic bronchitis and reduced function of the lungs. All these are due to prolonged exposure to PM2.5. There is no need to worry as we have the best product at your service. Making use of the antioxidant properties of curcumin, our miracle component called Pollutamin- PM2.5 will provide the protection from pollution that you need for yourself and your family members. Incorporate it in your daily intake and the benefits that you will get from it will be manifold. The antioxidant properties of curcumin are very much present in Pollutamin -PM 2.5 which will protect you from the polluted air that we all have to forcefully breathe leading to hazardous troubles and health worries. Following are the many amazing qualities that Pollutamin PM 2.5 from Bagdara Farms possesses: It is gluten free and very helpful to lower the effect of the harmful air we breathe. Since it is farm grown, it is totally free of chemicals and pesticides and harmful fertilizers as well. It has amazing anti-viral and anti-fungal properties that make it best for warding off infections like bronchitis and other lung and heart worries. It is also anti-inflammatory owing to the curcumin content that it has which makes it effective against lung problems that happen due to particulate matter in the contaminated air. Manufactured from home grown processes that are totally organic, Pollutamin-PM2.5 is your ideal bet for lessening the harmful and hazardous effects to the health of your family that is caused due to the prevalent pollution in cities these days. Order your jar of health and wellness from Bagdara right away! Click here for more details : https://www.ncbi.nlm.nih.gov/pubmed/27600540