Manage Melanoma with Curcumin
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2022/03/PTT-20190220-WA0002-1.mp3″] Skin is the largest organ in our body and if we were to open it up, it can cover up to several kilometers in length. Having said so, skin cancer is also becoming one of the leading cancers in the whole wide world. Skin cancers are the cancers are arising in the skin due to the uncontrolled growth of abnormal squamous cells. These rogue cells have the ability to invade or spread to other parts of the body too. There are different types of cancer cells that can arise in the basal cells, squamous cells, or the melanin-producing cells called melanocytes. Melanoma- Cancer of melanocytes is called melanoma. The common symptoms are redness or swelling that can spread to the border of a spot to the skin in the surrounding area. Itching, pain, and tenderness are also some of the symptoms here. It is a rare yet dangerous form of skin cancer. Non- melanoma- The cancer of basal and squamous cells are classified as non-melanoma skin cancer. It is a more common form of skin cancer. Skin cancer mostly appears on the face, neck, arms, hands, etc i.e. the parts of the body that are exposed to the ultraviolet radiations of the sun. What these rays do is that they damage the skin DNA which then eventually manifests into cancer. Some other risk factors associated with skin cancer are severe sunburns, old age, genetics, light-colored skin, freckles, having many large thick moles, and excessive use of the tanning beds. It has also been observed that people with skin diseases like psoriasis and weak immune system are also at high risk of having skin cancer. The most common signs and symptoms of skin cancer are the presence of sores, ulcers that don’t heal soon, moles whose appearance changes (become white and waxy lump like) as well as the presence of brown patches on the skin that become scaly and itchy. As we are all aware, the most common form of treatment for skin cancer is chemotherapy and radiotherapy which comes with its own share of side effects. One of the most effective and proven natural ways of treating as well as preventing cancer is the use of turmeric. Obtained from a plant called Curcuma longa, turmeric is a popular spice used for its vibrant color and aromatic flavor. Since time immemorial, it has been proved that turmeric has great medicinal properties like an antiseptic, analgesic, anti-inflammatory, antioxidant, anticancer, and immune-modulatory. All these properties can be attributed to the presence of the most bioactive compound in turmeric known as curcumin. Properties of Curcumin which make it Potent in Fighting Skin Cancer Inhibition of angiogenesis and tumor growth Angiogenesis is the term given to the formation of new blood vessels which helps in supplying more blood to the growing cells. On the flip side, the cancer cells can trigger this process so that the cancer cells get more supply of blood and also spread to the other parts of the body. VEGF (Vascular endothelial growth factor) is said to play a vital role in the development of skin cancer. Curcumin has the ability to inhibit angiogenesis. How does it do that? It inhibits various molecules of the signal transduction pathways which help in the process of angiogenesis. Provides protection from UV radiation The antioxidant property of turmeric helps to prevent the damage caused by UV radiation by scavenging the free radicals. Topical application of turmeric has a protective effect on the skin against UV rays as well as chemical-induced skin tumors. Immune system booster A suppressed immune system also is a major risk factor for skin cancer as stated earlier. The immune system does an important job of controlling cancer by identifying and eliminating cancer cells. Boosting of the immune system, also called immune therapy involves strengthening the immune system in the very first place to act against cancer. Regular consumption of curcumin helps to make the immune system stronger as it is a great immunomodulatory agent. Apoptosis Curcumin also helps to induce apoptosis (cell death) in both types of cancer (melanoma and non-melanoma). It does so by increasing the levels of p53 protein and interfering in various molecular pathways. Protection from the effects of radiotherapy and chemotherapy It has been seen that the anti-inflammatory and antioxidant effects of curcumin help in protecting against the side effects of radiotherapy and chemotherapy on the circulatory and nervous system. Both the oral consumption and topical application of curcumin helps in minimizing the effects of radiotherapy. Turmeric paste and curcumin-based ointments are a good option for the treatment of skin cancer. It is to be noted that curcumin needs to be started in small doses initially and gradually increase the dosage. Avoid taking it on an empty stomach to avoid any kind of acid reflux. A patch test is advisable before topical application. The use of a good brand of curcumin is of utmost importance for better results.
Breast Cancer – Does Curcumin Have Chemopreventive Effects That Work Against It?
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/02/breast-cancer.mp3″] Breast cancer is a disease that is quite common amongst both women and men all over the world. This form of carcinoma, like most others, can be categorized into two types – Invasive and Non-Invasive – depending upon its stage and aggressiveness. When the cancer cells are localized in one part of the breast and have not yet attacked the neighboring tissues, the carcinoma is known as non-invasive. During this period the abnormal growth can be cleanly extracted and in most cases, there is a very minute chance of relapse. On the other hand, when the cancer cells grow unabated and capture portions of tissues in regions surrounding the breasts like the armpits as well as the lymph nodes, then at this stage the cancer is of the invasive variety. Often the first signs of breast cancer are the emergence of an unusual lump in or around one or both breasts. Such lumps are either caught while doing a self-examination which is recommended for both men and women. They can also be spotted by a physician during an annual mammogram. Once a cancerous lump is detected there are several standard treatment protocols that are chosen based on the intensity of cancer. Surgery is a treatment method that is known to be most effective but it cannot be chosen for many cases where cancer has spread. Radiation therapy and chemotherapy are also treatment protocols that are often used to treat breast cancer. These methods are often very rigorous and cause many painful side-effects. This is perhaps the reason why many people have begun believing in augmenting standard treatment methods with natural therapies. Out of all the natural substances that are known to be effective in cancer management, curcumin is the most potent. A polyphenolic pigment extracted from the spice turmeric, curcumin is chockfull of therapeutic properties. One of the most amazing abilities of curcumin is to stop or reverse carcinogenesis which is the process of the development of cancer cells. This property is known as chemoprevention. Here are some ways in which this property of curcumin works well against breast cancer cells: Curcumin can reduce the production and activity of MMP-2, a compound that promotes the process of cancer development. Curcumin works as a cytotoxic agent and downregulates the production and activity of Bcl-2 and upregulates Bax, both of which are compounds that inhibit cell death or apoptosis in H-Ras MCF10A cells linked to breast cancer. A common toxin found in household products, BPA, has the ability to promote the creation of estrogen-responsive breast cancer cells. Curcumin can successfully put a halt to the proliferative effects of BPA by blocking miR-19. Curcumin is able to stop the growth of breast cancer cells by inhibiting Skp2 protein which promotes the progression of breast cancer. It also induces p27 in MDA-MB-231 human breast cancer cells to curb their growth. Curcumin triggers apoptosis through the PI3K/Akt signaling pathway. It also triggers a process known as Akt phosphorylation that selectively induces apoptosis in breast cancer cells. It is important to make sure that if you are suffering from breast cancer or a high-risk candidate for it, you choose a curcumin supplement that is pure and unadulterated. Aside from that, here are a few more things that one must ascertain before buying a curcumin supplement to help improve the effectiveness of breast cancer treatment. Curcumin should have the following properties It should contain organically grown curcumin as this is the purest kind and contains no harmful chemical residues. It should be made using wild strand curcumin as this variant of curcumin is much more effective in clearing GI infections It should contain non-polished curcumin so that all its nutritional benefits are intact It should contain curcumin that is not genetically modified. Ingesting genetically modified products can cause more harm than good. The curcumin used in it should be free of chemical fertilizer and pesticide residue. These artificial compounds can trigger many health issues including the development of abnormal carcinogenic cells. Carcirid is one such supplement that satisfies all the above criteria and can be taken without any fear by all breast cancer patients.
Chemopreventive Action Of Curcumin Against Lymphoma
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/Lymphoma.mp3″] A healthy immune system is like an inbuilt armor that helps keep disease-carrying foreign invaders at bay. Unfortunately, though, this internal mechanism is itself vulnerable to a variety of illnesses that can weaken it, therefore, making it ineffective in its primary task of protecting the body. One of the most severe conditions affecting the immune system is Lymphoma, a form of cancer that impacts lymphocytes, commonly known as white blood cells. Lymphocytes are an integral part of your body’s immune system. They are blood cells that possess the ability to generate antibodies that target disease-causing bacteria, viruses, and other toxins. Lymphocytes can also identify and neutralize those cells in the body that have been taken over by pathogens. In a way, they are like the front-line soldiers responsible for safeguarding your health by battling and defeating threats of all kinds. Lymphoma affects these fearless soldiers and renders them incompetent in the face of enemy invasion. Hodgkins Lymphoma is a variant of this disease that affects B lymphocytes and causes lymph nodes to swell up. Some of the common symptoms of lymphoma are: Swollen lymph nodes that are not bothersome or painful Fever without the presence of any infection Effortless loss of weight Profuse sweating at night Chronic fatigue Itching all over the body Risk Factors of Hodgkin’s Lymphoma: Previous incidents of Epstein Barr Infection or Mono An inherently feeble immune system Age groups 15 to 24 and over 55 years History of lymphoma in the family Curcumin As An Augmentative Therapy For Hodgkins Lymphoma In the case of Hodgkins Lymphoma, the one pathway that is seen to be deregulated is the Nuclear Factor Kappa B or NF-kb. Malignant cells of this kind are often seen to have a gene expression profile that sets these cells apart from the normal cells produced by a healthy immune system. The most common treatment protocols used to treat patients suffering from Lymphoma are chemo and radiotherapy. Unfortunately, while the success rate of these methods is high, there are several dangerous side effects that are also linked to them. These include – cardiotoxicity, secondary malignancies, and inability to conceive. A natural substance known as curcumin which is extracted from turmeric has shown a lot of potential in the form of an augmentative therapy for Lymphoma patients. Curcumin is a polyphenolic pigment that possesses many therapeutic properties. Ways in which Curcumin can be helpful in improving the outcome for Lymphoma patients: Lymphoma patients often have a high rate of production of NF-Kb and its related family members. Elements that keep a check on the production of this factor are also mutated in the case of Lymphoma. NFKBIA and TNFAIP3 are two such examples of mutated NFKB inhibitors. Since these elements are mutated, NF-kb production runs unregulated. Curcumin is able to block the inflammatory and pro-cancer activity of excess NF-kb by stabilizing one of these elements, NFKBI. Sometimes, certain treatment methods also trigger the overproduction of NF-kb. Curcumin supplementation can stop such an action as well. Curcumin is also able to check the action of TFR and therefore prevent the excessive production of NFKB in cancer cells. Curcumin reduces the cell viability of HL cells while safeguarding normal peripheral blood mononuclear cells. Besides, curcumin supplementation causes cell cycle arrest. Curcumin acts as a natural HDAC-suppressor thereby making Lymphoma cells much more sensitive to cytotoxic drugs. This helps in improving the results of standard chemotherapy. Curcumin stops the Epstein Barr virus from immortalizing B-cells. Cells that have already been affected by the virus also have a higher chance of going through apoptosis in the case of curcumin supplementation. Curcumin reduces the production of BCL-XL, a mutated isoform of the B cell leukemia/ lymphoma 2 (BCL2). A reduction of this compound has shown a strong correlation with better outcomes in Lymphoma patients. Here are a few things that one should keep in mind while selecting a curcumin supplement for Lymphoma patients: The curcumin should come from a wild strand The curcumin used should not be treated with chemical fertilizers and pesticides The curcumin should be devoid of chemical residues The curcumin should be organically grown The curcumin used should not be genetically modified. Oncomin is a supplement created by Bagdara Farms and is perfect for Lymphoma patients as it satisfies all the above-mentioned criteria.
Can Lung Cancer Patients Rely On Curcumin Lessen Their Agony?
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2022/03/PTT-20190218-WA0013-1.mp3″] Lung cancer is a disease that is often attributed to smoking. However, there are some other uncontrollable factors too that make a person vulnerable to this disease. These factors include exposure to polluted air for a prolonged period and genetics. Lung cancer occurs when there is a development of abnormal cells in the lungs which leads to the creation of tumours. These tumours disrupt the regular functioning of the lungs, thus causing physical symptoms like shortness of breath, a long-lasting cough, pain while breathing, and specks of blood in coughed-up phlegm. Two Main Types Of Lung Cancer: Non-Small Cell Cancer – This variant of lung carcinoma is the most prevalent kind and the majority of lung cancer cases fall in this category. Small Cell Cancer – This is a less common but more aggressive form of lung cancer. What Is Angiogenesis Targeted Therapy While today the most common treatment methods for lung cancer include surgical extraction of tumours wherever possible, chemotherapy, and radiation therapy, there has been an increased focus on alternative methods of containing the progression of cancer. One such method that has been researched extensively of late involves targeting tumour angiogenesis pathways using natural anti-angiogenic substances. In order to understand this approach, it is vital to first learn more about angiogenesis and its impact on cancer. Angiogenesis is a normal physiological body process that creates new capillaries to supply nutrient-rich blood to parts of the body that require more supply. In a healthy body, angiogenesis occurs either when the body is going through a growth spurt or when the body is recovering from a wound. In the case of lung cancer though, angiogenesis is erroneously triggered by the rogue cancer cells in order to create a blood supply that can feed the tumours growing in the lungs. This process not only allows the tumours to thrive and grow but also enables cancer cells to move to other parts of the body. The excessive production of pro-angiogenic factors in lung cancer patients occurs as a result of tissue hypoxia. Out of all these factors, one of the most active sets of protein factors that cause heightened angiogenesis in cancer patients is the VEGF group or the Vascular Endothelial Growth Factor. This includes VEGF A to VEGF-D as well as PIGF which is a placenta growth factor. This type of protein attaches itself to VEGF receptors like VEGFR-2 and causes processes like endothelial proliferation, increased permeability of tissue, and the creation of new blood carriers that can supply blood to tumours. How Does Curcumin Work As An Anti-Angiogenic Agent In Lung Cancer? Curcumin is a polyphenolic pigment extracted from the spice turmeric. It has multiple therapeutic properties that make it extremely important as a healing agent in case of many ailments. In the case of lung malignancies, curcumin can be very beneficial as it has anti-angiogenic effects. Here are some ways in which it exerts these effects and reduces the severity of the disease: STAT3 is a molecular pathway that is directly correlated to VEGF over-expression. Extreme STAT3C activity tends to trigger angiogenesis in tissues forming the tumours. It has been observed that in the case of non-small cell cancer of the lungs, regular consumption of curcumin can help inhibit the STAT3 pathway which in turn can lower the expression of VEGF and subsequently block angiogenesis in cancer cells. Another protein that promotes the creation and survival of cancer cells is BclxL. The primary action of this protein in the case of cancer cells is its anti-apoptotic activity which inhibits the cell death procedure in cancer cells. Curcumin downregulates the expression of this protein as well thereby allowing apoptosis to occur in cancer cells. Regular consumption of curcumin helps contain tumour growth by keeping tumour cells in check as well as preventing the proliferation of endothelial cells. Curcumin has strong anti-inflammatory properties that inhibit the excessive activity of the NF-kb pathway which is also responsible for inducing angiogenesis in tumours. Although these results are exciting and hold a great deal of promise for lung cancer patients, it is vital to keep in mind that the quality of curcumin that you are ingesting is very critical too. The Points To Be Kept In Mind While Selecting An Appropriate Curcumin Supplement: The curcumin used in the supplement should be a product of a wild strand. The curcumin used in the supplement should not contain chemical residues The curcumin supplement should be grown organically and with natural manure The curcumin should not be treated with artificial pesticides and fertilizers The curcumin should be devoid of any kind of adulterants The curcumin should not be genetically modified. Oncomin, a top-notch product created by Bagdara Farms, satisfies all of the above criteria and is, therefore, the most ideal supplement for cancer patients.
CURCUMIN AIDS AS AN EFFECTIVE ANTI CANCER AGENT IN ASSOCIATION WITH CARBOPLATIN
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/Anticancer-with-Carboplatin.mp3″] Chemotherapy is one of the most viable agents used for cancer treatment for many years even though it has its share of side effects. The most commonly used chemotherapeutic agent is a platinum-based drug. The first generation platinum agent like cisplatin offers great anticancer properties but its usage is limited due to its very serious side effects like neurotoxicity, nephrotoxicity, and ototoxicity. After rounds of research, a second-generation platinum drug called carboplatin was developed which was seen to have lesser serious side effects except for myelosuppression. What is Myelosuppression? This is a condition in which bone marrow activity decreases resulting in very few red blood cells, white blood cells, and platelets. Some of the common symptoms of myelosuppression are: Easy bruising bleeding in the nose, gums, and mouth due to low platelets Fever, chills, and rashes Fatigue, pale skin, and nails due to low red blood cells count Anemia All the above symptoms are seen as the process of chemotherapy kills the important cells present in our blood. About 20-40% of patients who have been treated with conventional doses of carboplatin experience this kind of side effects. The main challenge has been to reduce the side effects of carboplatin on the overall health of the patient as it is a good chemotherapeutic agent. Can Curcumin be of Some Assistance in Curbing the Side Effects of Carboplatin? Many studies have shown that curcumin does ac like a great anticancer agent when used in combination with carboplatin. Curcumin is a natural polyphenol that has been used since time immemorial as a great anti-inflammatory agent that prevents the proliferation of tumour cells. Curcumin is known to show significant antiproliferative and apoptotic effects in many tumour cells. Since curcumin is also a good antioxidant agent, it inhibits the formation of reactive oxygen species. An experiment was carried out when the C57B6 mice were injected with T241 fibrosarcoma cells. The division was done in such a way that four groups of mice were treated with a series of intraperitoneal injections of 20% Tween 80 ( control), only curcumin, only carboplatin, or a combination of curcumin and carboplatin. The results showed that the inhibitory effects on tumour volume seen in the mice treated with combined drugs were stronger than that of the other two groups of control and carboplatin group. This means that curcumin has the ability to attenuate the side effects which are induced by carboplatin to improve the survival of cancer patients. How does Curcumin help in Reducing the Side Effect of Carboplatin? It was also seen that treatment with curcumin and carboplatin can significantly help to improve carboplatin-induced bone marrow damage by helping the reappearance of bone trabecular and defibrillation hematopoietic cells. Curcumin also improves DNA damage induced by the use of carboplatin in bone marrow cells. In other words, we can say that it helps in the DNA repair pathway. Lesions in the DNA caused by the use of platinum drugs were repaired by a combination of homologous recombination and nucleotide excision repair. One of the major side effects of carboplatin treatment is nephrotoxicity wherein the kidney accumulates a very high concentration of cisplatin as compared to any other organ. To be specific, it affects the terminal part of the proximal tubule and the distal nephron leading to either necrosis or apoptosis. As mentioned above, curcumin prevents the formation of free radicals, thus reducing platinum-based drugs related to the production of ROS. By increasing the tolerance of bone marrow cells to chemotherapy-induced toxicity, curcumin can tackle the side effects of this second generation of the platinum agent. It is also known to reduce the cisplatin-induced clastogenesis by acting as a scavenger of free radicals.
Curcumin’s Antiangiogenic Properties Can Help Cervical Cancer Patients
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/Anti-angiogenic-For-Cervical-Cancer.mp3″] One of the most important parts of a woman’s reproductive system is the cervix. It forms a bridge between the uterus and the vagina and unfortunately, it is highly vulnerable to a rather deadly form of cancer known as cervical cancer. This type of malignancy develops in the cells of the cervix and turns them into abnormal cells that grow rapidly and turn into tumors. The tumors that appear in the cervix are usually very vascular and are known to bleed. Most cases of cervical cancer occur in the squamous cells that line the cervix and are hence known as squamous cell carcinoma. A smaller percentage of cases are caused as a result of cancerous growth in the mucus-producing glands in the cervix. These are known as adenocarcinomas. One of the most common causes of cervical cancer is an infection caused by the human papillomavirus or HPV. This sexually transmitted disease increases one’s risk of developing cervical cancer in the future. Symptoms of Cervical Cancer: At first cervical cancer may not trigger any symptoms. In its advanced stages though, it is known to cause: Abnormal vaginal bleeding that occurs in between the regular menstrual cycle or after intercourse Pelvic heaviness and pain Watery, smelly vaginal discharge Excessive urination and pain while urinating. What Are Antiangiogenic Substances And How Do They Work? Aside from the usual cytotoxic cancer therapies prescribed by physicians to deal with this form of cancer, an additional antiangiogenic treatment method can help speed up the recovery process. This is because natural antiangiogenic substances usually do not affect the endothelial cells, thus ensuring that the healthy portions of the body stay healthy during the course of the treatment. Angiogenesis is a normal physiological process that is triggered by the body to create new capillaries that can feed certain portions of the body. This process occurs more often during a child’s growth spurt or when the body is going through a phase of healing. While in a normally functioning body angiogenesis is nothing to worry about, in case of cervical cancer, an accelerated rate of angiogenesis leads to the formation of blood vessels that feed the cancerous growth allowing it to thrive. In cervical cancer patients, there are numerous biological molecules that accelerate the angiogenesis process. Some of these are EGFR, COX-2, and VEGF. Out of these VEGF is the most prominent one. It promotes the movement of endothelial progenitor cells. COX-2 suppresses the body’s ability to induce apoptosis in cancer cells. Out of all the natural antiangiogenic substances, curcumin is the most potent one. Extracted from the spice turmeric, curcumin is a polyphenolic pigment that possesses a rich cache of therapeutic properties. In the case of cervical cancer too, curcumin can help contain tumor growth by doing the following: The human papillomavirus is known to heighten the production of VEGF by increasing the E6 oncoprotein level. Also, this virus pulls down the level of expression of antiangiogenic factors like TSP-1 and TSP-2. A daily dose of curcumin can help reduce the quantity of VEGF produced and hence minimize the rate of angiogenesis. Curcumin also has the ability to reduce the production of COX-2, a molecule that hampers the effectiveness of the body’s immune system, stops the body from inducing apoptosis in cancer cells, and makes malignant cells much more invasive. Curcumin can inhibit the production of EGFR too which is responsible for worsening the prognosis of cervical cancer patients by making their tumors much more aggressive and prone to metastasis. While choosing a curcumin supplement to battle cervical cancer it is important to keep the following in mind: The curcumin used to make the supplement should come from a wild strand. The curcumin used should not be genetically modified. The curcumin in the supplement should have been cultivated organically. The curcumin in the supplement should not be treated with chemical fertilizers and pesticides. The curcumin in the supplement should be free of chemical residue and adulterants. Cervikil, a curcumin enriched supplement created by Bagdara Farms has all the above properties and is therefore perfect for cervical cancer patients.
How Curcumin’s Anti-Angiogenesis Properties Help Cancer Patients
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/angiogenesis.mp3″] Have you ever wondered if your blood vessels have a lifecycle? Well, they surely do. In fact, a process known as angiogenesis runs constantly within your body and allows existing blood vessels to sprout new ones all the time. A layer of endothelial cells forms a cushion inside blood vessels. As part of angiogenesis, these cells may migrate and grow to form new capillaries either in the existing location or in places where they are needed. This process runs rapidly during a child’s growth spurt or when the body is recovering from a health condition and is in the healing phase. The governing elements for angiogenesis are chemical signals that are generated by your body. Signals like VEGF are received by receptors present on the surface of endothelial cells, triggering them to grow new vessels. On the other hand, the body also generates signals that discourage the process of angiogenesis. These two types of chemical signals help maintain a balance so that blood vessels are generated only when needed and not in excess at any given time. One of the most dreadful outcomes of a malfunction in this balancing act played out by your body is the swift development of malignant growths. When abnormal cancer cells develop within your body, they give rise to tumors. These tumors require a constant supply of blood to thrive which is why they begin sending out signals to your body to stimulate the angiogenesis process. As a result, the body creates new blood vessels around the tumor which feed it constantly thus allowing it to grow uninhibited. Similarly, these blood vessels make it easier for cancer cells to take over surrounding tissues as well and move around the rest of the body, forming colonies all over. This results in metastasis, a phenomenon that spells doom for cancer patients. In most cancer treatment protocols, the use of angiogenesis inhibitor drugs is common. These drugs work well as they are able to stop the creation of new blood vessels and can, therefore, starve the tumor. This line of treatment focuses on cutting off the tumor’s nutrition supply instead of attempting to stop the development of tumor producing cells. Since chemical drugs are known to have side effects that can give birth to harsh symptoms, there is an increasing interest in finding natural substances that can inhibit angiogenesis. One such substance, a polyphenolic pigment found in turmeric, has proven time and again that it can work just as effectively as any angiogenesis-inhibiting drug in the market. This natural wonder is known as curcumin. Curcumin has many therapeutic qualities including being a potent antioxidant, an anti-inflammatory agent, and a broad s[ectrum anti-microbial agent as well. As an Angiogenesis Inhibitor Curcumin works as follows: VEGF is one of the primary signaling mechanisms that give rise to angiogenesis. Curcumin interferes in the activity of this chemical signal by hampering COX-2 and MAPK. It also reduces the expression of VEGF. Curcumin pulls down the level of expression of angiopoietin 1 and 2 in the abnormal cells that form the tumor. It also puts a barrier in the smooth VEGF production in the tumor cells by bringing down the expression of HIF1-alpha. Curcumin can ensure that blood vessel producing cells do not move towards malignant growths. By inhibiting the activity of proteins like u-PA and MMP curcumin successfully cuts down the generation of growth factors that eventually lead to the formation of new capillaries. Curcumin can bring down the effectiveness of adhesion molecules that are present on endothelial cells and which makes it possible for these cells to attach to other cells. This activity helps prevent the growth of a tumor as well as the process of metastasis. In most of the forms of cancer, the beginning is marked by a small malignant growth that slowly grows in size and also leads to the formation of other growths all over the body. As explained above, it is the process of angiogenesis that works erratically to fuel such activity within your body which is why it is all the more important to find ways to put a brake on it. Oncomin, a curcumin enriched supplement created by Bagdara Farms is a perfect natural angiogenesis inhibiting remedy that has all the properties that make it safe for consumption. How Curcumin from Bagdara Farms is Different? The curcumin used in Oncomin comes from a wild strand, making it much more effective. The curcumin used is grown organically The curcumin crop is not treated with artificial pesticides or fertilizers The curcumin used is not genetically modified.
Are You Always Tired? This Could Be An Early Symptom of Cancer… Find out
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2022/03/apoorva-cancwrsymptoms.mp3″] Timing is an essential element in our efforts to pursue any objective. The often-repeated adage that action delayed is action denied holds by the fullest sense of the phrase in every aspect of our lives whether personal, financial, professional and more relevantly, our health. During the grind of our daily commitments, we tend to be more naturally inclined to the first three spheres, while health is always accorded a low priority. In the process, we often choose to ignore symptoms that our bodies throw up from time to time. At times these symptoms disappear on their own, while at many a time, they may indicate something more serious, i.e. nesting of cancer cells in our system. According to a new study by Cancer Research in the U.K., a majority of adults have been exposed to signals from their bodies that could mean cancer. Only a minuscule percent of them believed cancer could be a possible cause. A few cancer symptoms which should not be ignored are brought out below : Unexpected Weight Loss – It is a matter of delight for all to experience weight loss without putting in any conscious effort. But what is not known to most people that this could be a symptom of cancer unless of course, the loss of weight is caused by a hyperactive thyroid gland? Hence, any increase or decrease in weight loss that is unintentional, should not be ignored. Bloating – We have reconciled to the fact of bloating by attributing it to being a common and normal phenomenon. However, if it continues for a relatively long time span, then it merits attention. Other associated symptoms like (1) urinary problems, (2) pain in the pelvic region as well as the (3) feeling of being full without having eaten much, can be a symptom of ovarian cancer. Changes in the Breast – Due to increased breast cancer awareness, many women have learned the method of self-examination of the breast. Normally, lumps are a most sought-after symptom but are informed that this is not the only symptom. Redness and thickening of the breast skin should also not be ignored at any cost as well. Any persistent rash over the course of time will need medical attention and advice. Discharge from the nipple even if a woman is not breastfeeding, can be an indication of cancer of the mammary glands. Continuous bleeding – This can be experienced by both, men and women. Any unusual or Irregular bleeding should never be ignored. Unfortunately, mainly due to ignorance, many premenopausal women tend to ignore this which can be a symptom of uterine, endometrial, or colorectal cancer. This merits immediate medical attention. Further, rectal bleeding with dark blood is reason enough should be enough to visit the doctor. Discomfort while Eating – Another common form of cancer is esophageal cancer. The most common symptom is when a person experiences difficulty or discomfort while swallowing food. Any persistence of this should be followed up by a thorough check-up or as advised by a doctor. Enlargement of Lymphs – Though swellings in the neck are fairly common when suffering from a viral infection, any enlargement in the lymph nodes on the neck or in the armpits persisting for over a month should merit medical attention. Moreover, neck growth can also be a sign of blood cancer and lymphoma. A thorough examination by a specialist is a must to rule out anything. Skin changes – Any change in the size, shape, or color of a mole or other spot on your skin, is reason enough to visit the doctor at the earliest. Spots that are new or look different are significant signs of cancer. Fatigue – Many types of cancer induce bone-deep tiredness that can never be got over with despite any quantum of rest one may indulge in. It is not the same as we may feel after a lot of activity. The persistence of fatigue which interferes with our sm daily routine is cause enough to seek medical advice. It is seen that more often than not, fatigue occurs in the early stages of cancer due to internal bleeding. The initial sign could be fatigue and exhaustion, as well as shortness of breath, palpitations, and ankle swelling. Early detection of cancer can be hugely instrumental in increasing the chances of full recovery thereby enhancing survival.
Did You Know Taking This Regularly Could Prevent You From Breast Cancer Forever?
Breast cancer accounts for 25% of all cancers found in women. While there are numerous clinical treatment protocols that are followed during the treatment of breast cancer, it is also vital to know that the effectiveness of these therapies can be augmented by natural remedies. Carcirid, a curcumin enriched supplement created by Bagdara Farms has anti-carcinogenic, anti-inflammatory, and antioxidant effects that can help patients heal faster. The month of October has been chosen worldwide as Breast Cancer Awareness Month. Now, more than ever, it has become crucial to spread as much knowledge about breast carcinoma as possible especially since catching this dreadful disease in its nascent stages is the key to full recovery. As is the case with all other forms of cancer, in breast cancer too, a presence of abnormal cells that multiply at an unusually high rate leads to the formation of a malignant mass. Such a mass may continue to grow in size if not detected and treated quickly. All key elements of the breast are susceptible to cancerous growths, including the ducts that are responsible for transporting breast milk to the nipple, lobules that are responsible for producing the milk, and tissue. The first step towards winning the battle against breast carcinoma is understanding how to identify it early on. Here are some of the typical symptoms that every woman should be checking for on a regular basis. Symptoms to Watch Out For? Altered shape or size of the breast Unusual discharge that has spots of blood Growth in the armpit that looks like swelling An atypical rash around the breasts The treatment of breast cancer usually involves a combination of surgery, chemotherapy, and radiotherapy. Depending on the extent of proliferation, physicians decide if removing the mass surgically is an option or not. Chemotherapy uses strong drugs to attack and annihilate cancer cells while radiotherapy uses high-intensity x-rays. To increase the efficacy of these treatment methods, a natural remedy that involves the consumption of curcumin is most effective. Curcumin, a compound that is extracted from the turmeric plant, is loaded with therapeutic properties that not only help fight cancer but also makes cancer cells more sensitive to chemo drugs, therefore, improving the outcome of such an intervention. There are numerous direct effects of curcumin on breast cancer. How Curcumin Helps in Preventing Breast Cancer Curcumin has the ability to hamper the activity of an enzyme known as Telomerase which is responsible for promoting the non-stop multiplication of cancer cells in tumours. By doing this, curcumin ensures that the cancerous lump in the breast does not grow uncontrollably and is limited to the breast, making it easier for surgeons to extract it completely and ascertain full recovery. Curcumin exhibits excellent anticarcinogenic properties. It has the ability to spot cancer cells in the breasts and attack them specifically. By rupturing the cell membranes of such cells, curcumin is able to quickly induce cell death or apoptosis, thus containing cancer. It is also able to control the apoptosis-related proteins in the body to fasten the process of cell death amongst cancer cells. Curcumin can control some signalling pathways in cancer cells that makes it possible to put a cap on cell division, proliferation, and metastasis. Curcumin also has the ability to reverse the resistance developed by cancer cells towards chemo drugs. By making cancer cells sensitive to these drugs, curcumin ensures that the effectiveness of chemotherapy is not reduced. The anti-inflammatory effects of curcumin are brilliant when it comes to battling post-surgery pain. Since the effect of curcumin has been compared and found equal to the effect of standard painkillers, it is better to rely on curcumin instead of artificial drugs as it does not have any after-effects. Not only does curcumin help manage pain better, but it also helps heal the incision made during surgery faster. Carcirid, a curcumin-based supplement created in the lush green premises of Bagdara Farms in Katni, Madhya Pradesh, is a one-of-a-kind curcumin supplement that solely targets breast cancer and is made keeping in mind the requirements of breast cancer patients. The quality of curcumin used in Carcirid is much superior to most other supplements because it is grown using organic farming techniques at the Bagdara facility. Such an emphasis on organic farming ensures that the curcumin that is going into your jar of Carcirid has no unwanted chemical residues or adulterants that can be potentially dangerous for your health. If you are struggling with breast cancer, try Carcirid, and see how quickly it can melt your worries away.
Cholangiocarcinoma Can Be Cured With Curcumin
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/04/Cholangiocarcinoma.mp3″] Bile is one of the digestive juices that help in the emulsification and breakdown of dietary fats. It is secreted by the liver and is taken to the gallbladder for storage through many pipes called bile ducts. From the bile ducts, the bile is taken to the small intestine where it breaks down fat. Cholangiocarcinoma is a type of cancer that arises in the bile ducts which is quite rare and occurs mostly in people above the age of 50 years. They are a part of a family of tumours called adenocarcinomas. Depending on the part of the cancer of bile ducts that a tumour grows, Cholangiocarcinoma can be divided into three types: Intrahepatic cholangiocarcinoma- This type of cancer occurs in the area of the bile duct which is within the liver. Hilar cholangiocarcinoma- it occurs in the part of the bile duct which is just outside the liver. Distal cholangiocarcinoma- this occurs in the bile duct that is nearest to the small intestine. Symptoms of Cholangiocarcinoma Are As Follows: Dark urine and pale white-colored stool A condition of yellowing of skin, nails, and eyes is called jaundice Excessive itching due to jaundice Fever Loss of appetite Fatigue and weight loss Pain in the abdominal region that penetrates in the back as the cancer growth increases The main cause behind cholangiocarcinoma is the random change or mutation which occurs in the DNA of the cells of a bile duct. Once the mutation occurs the cells lose control of the division of cells forming a tumour. The real reason why the mutation occurs is not known. Having a history of chronic liver disease increases the risk of cholangiocarcinoma. A health condition called primary sclerosing cholangitis causing scarring and hardening of bile ducts also cause cholangiocarcinoma. Problems with the bile duct at birth like choledochal cyst can fall prey to this chronic disease in the future. Excess of smoking and liver fluke infection can be a high-risk factor for getting affected by cholangiocarcinoma. Even after this type of cancer has been treated successfully, surgeries may have to be performed in order to open up the blocked bile ducts. The correct diagnosis of cholangiocarcinoma can be done by a few tests like liver function tests, tumour marker tests, and imaging tests like ERCP, CT scans, and MRI scans. Curcumin is a potent anti-cancer agent due to its antioxidant and anti-inflammatory properties. Oncomin from Bagdara Farms helps in treating and preventing Cholangiocarcinoma.
Treat Mesothelioma with Curcumin
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/mesothelioma.mp3″] Mesolithium is the thin layer of tissue that covers almost all the internal organs of the body like the heart, lungs, and abdomen. Mesothelioma is an aggressive form of cancer that affects the mesolithium. A cure for mesothelioma is not possible in many people as it doesn’t include a benign form. Depending on the part of mesolithium which is affected by this cancer, mesothelioma can be divided into different types. If it affects the mesolithium that covers the lungs, it is called pleural mesothelioma. Those affecting the abdomen is peritoneal mesothelioma and the one affecting the heart is called pericardial mesothelioma. The Symptoms also vary According to the site at which Cancer develops: Pleural mesolithioma- it shows symptoms like pain while coughing, chest pain under the rib cage, shortness of breath, effortless weight loss and lumps on the tissues under the skin on the chest. Peritoneal mesothelioma- Some of the common symptoms of peritoneal mesothelioma are abdominal pain and swelling, excessive weight loss, lumps of tissue under the abdomen, etc. Testicles are also affected by mesothelioma and the first signs are swelling or a mass of growth on the testicles. Like many cancers, the main cause of mesothelima is also a genetic mutation in the DNA of mesothelial cells but one of the primary risk factors is exposure to asbestos. It is a naturally occurring mineral and is used as insulation in brakes, flooring, and many other things. During mining when asbestos is broken down, the asbestos dust can be inhaled or swallowed, it settles down in the lungs or stomach causing mesothelioma over a period of time. There can many other factors too contributing to the development of mesothelioma like a family history of mesothelioma and living with someone who is constantly exposed to asbestos. The affected person starts showing signs of mesothelioma after about 10 to 50 years after the initial exposure to asbestos and at times the early symptoms can be confused with that of flu or pneumonia. Sarcomatoid mesothelioma is the most aggressive form of mesothelioma, which can grow rapidly and even spread to various parts of the body and becomes extremely difficult to treat. The physician may carry out certain tests like X-rays and CT scans of the chest and abdomen to check for any kind of abnormalities. The biopsy can be done to find out the affected area and how aggressively it grows. Since curcumin is a great antioxidant and anti-inflammatory agent, it can help to fight off cancer cells. Bagdara Farms has the best quality curcumin as it is grown organically without any chemicals. Oncomin from Bagdara Farms helps in treating Cancer. Take Oncomin Regularly and stay away from Cancer.
Curcumin Comes To The Rescue In Case Of Cholangiocarcinoma – Rare Form Of Cancer
Listen To Article [sc_embed_player fileurl=”https://bagdarafarms.com/wp-content/uploads/2019/03/Curcumin-For-Cholangiocarcinoma.mp3″] Cholangiocarcinoma is a rare form of cancer that is known to afflict older people, especially after the 65-year mark. This is a disease that affects the tubes that are responsible for carrying bile throughout the digestive system. Bile is an essential fluid that is produced by the liver and then stored in the gallbladder. It is used to process fats and is vital to a well-functioning digestive system. When a cancerous growth develops in the ducts that carry bile, it could lead to an obstruction that can cause pain and jaundice-like symptoms. Unfortunately, these biliary tubes are vulnerable to malignancies throughout their length. Depending on where the cancer is located, this disease can be categorized into 3 main types: Intrahepatic bile duct cancer– These growths occur in the portion that resides in the liver Perihilar bile duct cancer – Here the malignant growth is at the point where the tubes leave the liver Distal bile duct cancer – Malignancies that occur towards the lower end of the tubes, closer to the small intestines. Symptoms of Cholangiocarcinoma: Jaundice Excessive Itching Abdominal Pain Loss Of Appetite Drastic Drop In Weight Fever Risk Factors of Cholangiocarcinoma Stones in the bile ducts can trigger inflammation that has the potential to act as a precursor to cholangiocarcinoma, especially if it is left unchecked for too long In many Asian cultures, eating raw or undercooked seafood is common. This could cause liver infections that can increase your risk. Excessive alcohol consumption or diseases like Hepatitis A or B can lead to a scarred liver that also makes it easier for cancer cells to form. Inflammatory bowel diseases like ulcerative colitis, which causes inflammation and the formation of scar tissue can increase the risk of carcinoma. Obesity paves the way for the formation of stones, therefore, increasing the probability of cancer. Aside from the regular treatment methods that are recommended by doctors, it can be beneficial to explore some natural remedies that have the ability to augment the efficacy of the standard allopathic treatments. One such natural gift that has shown quite a lot of potential is curcumin, a phytochemical found in abundance in turmeric. Curcumin beholds numerous therapeutic qualities that make it a popular choice amongst naturopaths and Ayurvedic doctors when it comes to treating a variety of health conditions. In case of severe illnesses like bile duct cancer to curcumin has proven its mettle. Here are some examples of the benefits that curcumin has in the case of cholangiocarcinoma: Once cancer cells develop in the body, they tend to thrive because there is a class of enzymes that promote cancer cell survival by deactivating those pathways that are meant to induce apoptosis or cell death in such cells. These elements in the body tend to trigger processes that create blood vessels around the cancer growth that feed it and allow it to grow. A daily dose of curcumin can help reverse the activity of these enzymes by triggering the pathways that induce cell death in cancer cells. It is helpful in completely cutting off the metabolic processes feeding these cancer cells, therefore, making their survival and growth impossible The symptoms of cholangiocarcinoma include fever and abdominal pain. The root cause of these signs is chronic inflammation unleashed by the cancerous growth. Chemo drugs and radiation therapy also cause certain painful after-effects that exacerbate the pain temporarily. Curcumin has strong anti-inflammatory properties that make it a wonderful cure for inflammation. The curcumin inhibits the activity of multiple pro-inflammatory pathways in the body like NF-kappaB and TNF-alpha, therefore combating chronic inflammation. Cancer cells sometimes become immune to chemo and radiation therapy. A regular dose of curcumin helps sensitize these anomalous cells to certain types of treatment drugs like the ones that contain platinum. It also deters the action of pro-survival proteins that keep cancer cells safe from radiation and drugs. Curcumin is also an antioxidant that can help reduce the quantity of harmful free radicals in the body by neutralizing them and thus reducing oxidative stress. This reduction in oxidative stress helps in making the body less conducive to the development of cancer cells. Bagdara Farms, a unique initiative in the field of agriculture that focuses primarily on the cultivation of high-quality curcumin that is then used to create supplements of all kinds. Oncomin is one of their offerings that is created especially for cancer patients. Taking Oncomin regularly can help those suffering from bile duct cancer by reducing the effects of cancer as well as improving the effects of chemo and radiotherapies.