DEALING ENDOMETRIOSIS WITH CURCUMIN
Women experience unique health care challenges and are more likely to be diagnosed with certain diseases than men.
Of the assessed 176 million women worldwide who suffer from endometriosis, around 26 million of them are Indian.
This figure is an estimate, because of the fact that many women remain undiagnosed. Because of poor understanding of the condition, this leaves many women simply trusting that symptoms are the natural results of their period.
Humiliation regarding women’s health issues, including sexual health issues and menstruation is common place in India. This humiliation plays a role in encumbering efforts to estimate figures.
What Is Endometriosis?
Endometrial tissue consists of glands, blood cells, and connective tissue.
It normally grows in the uterus, to prepare the lining of the womb for ovulation.
When they grow outside the uterus, this is called endometriosis. Endometriosis is a common condition in women. It’s chronic, painful, and often gets steadily worse.
How Can Curcumin Help Naturally?
In endometriosis cells, the NF-κB pathway, one of the main indicators of inflammation, can regulate the proliferation, apoptosis and inflammation processes observed.
Recent studies have shown the protective role of curcumin in combating inflammation. Curcumin in medicinal turmeric can lessen the activity of the NF-κB pathway.
Medicinal turmeric rich in curcumin can down regulate the expression of TNF-α, COX-2, IL-6 and TGF.
Curcumin is known to diminish inflammation by inhibiting the expression of inflammatory factors, such as the NF-κB pathway in the person suffering from endometriosis.
As a potent anti-oxidant, curcumin can target the TNF-α expression to progress the growth differentiation factor-9 (GDF-9) expression in peritoneal fluid of women with endometriosis.
A recent study shows that curcumin abundantly found in medicinal turmeric can be used as a powerful natural herb in the treatment of endometriosis by rescinding the aberrant activation of chemokines, cytokines, and the NF-κB pathway.
Fights oxidative stress in endometriosis
Oxidative stress is considered as one of the main causes of the endometriosis process.
Studies show that deterrence of endometriosis could be done by the administration of antioxidants.
Curcumin in medicinal turmeric has been associated with a decrease of ROS serum and lipid peroxidation. Moreover, therapy by curcumin in endometriosis can foil against lipid peroxidation and protein oxidation. Curcumin management can weaken OS by regulating the Nrf2-Keap1 pathway .
Curcumin and Invasion and Adhesion
The endometriotic peritoneum of women presents an overproduction of MMP, especially MMP-1, 2, 3, 9 and 11, and cellular adhesion molecules, including ICAM-1, integrins and cadherins.
In endometriosis lesions, curcumin constrains MMP-9 expression and can attenuate TIMP-1 expression.
Curcumin and Apoptosis
The PI3K/Akt pathway is activated in endometriosis cells which lead to apoptosis.
Recent studies have shown
That curcumin declines the number of endometriosis stromal cells and the process of cell growth in a dose-dependent manner.
The administration of curcumin found in medicinal turmeric is associated with the reduction of endometriosis development and the activation of apoptosis.
Curcumin administration leads to an increase in the ratio of pro-apoptotic factor Baw/anti-apoptotic factor Bcl-2, the initiation of cytochrome c and caspase 9, and tumour suppressor protein p53
Medicinal Turmeric is a healing and nurturing plant, offering protection from damage associated with modern day living as well as specific support for female health conditions.
Through its rich and varied plant chemistry, it has a powerful anti-inflammatory, antioxidant and immune-strengthening ability that can be a wonderful support for hormone balance at all life stages.
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